Multitarget Therapy for Maintenance Treatment of Lupus Nephritis
نویسندگان
چکیده
منابع مشابه
Multitarget therapy for induction treatment of lupus nephritis: a randomized trial.
BACKGROUND Treatment of lupus nephritis (LN) remains challenging. OBJECTIVE To assess the efficacy and safety of a multitarget therapy consisting of tacrolimus, mycophenolate mofetil, and steroid compared with intravenous cyclophosphamide and steroid as induction therapy for LN. DESIGN 24-week randomized, open-label, multicenter study. (ClinicalTrials.gov: NCT00876616). SETTING 26 renal c...
متن کاملSuccessful treatment of class V+IV lupus nephritis with multitarget therapy.
Treatment of class V+IV lupus nephritis remains unsatisfactory despite the progress made in the treatment of diffuse proliferative lupus nephritis. In this prospective study, 40 patients with class V+IV lupus nephritis were randomly assigned to induction therapy with mycophenolate mofetil, tacrolimus, and steroids (multitarget therapy) or intravenous cyclophosphamide (IVCY). Patients were treat...
متن کاملLupus nephritis: maintenance therapy for lupus nephritis--do we now have a plan?
Lupus nephritis (LN) increases the morbidity and mortality of patients with SLE. This review compares the randomized, controlled trials that examined various maintenance regimens available to treat LN. Currently, mycophenolate mofetil (MMF) and azathioprine (AZA) are the most popular therapeutic agents used for long-term maintenance of LN. Long-term maintenance with MMF is recommended as the fi...
متن کاملMycophenolate versus azathioprine as maintenance therapy for lupus nephritis.
BACKGROUND Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and prevent relapse after the initial control of lupus nephritis. METHODS We carried out a 36-month, randomized, double-blind, double-dummy, phase 3 study comparing oral mycophenolate mofetil (2 g per day) and oral azathioprine (2 mg per kilogram of body weight per day), plus...
متن کاملTreatment of lupus nephritis.
Renal involvement in systemic lupus erythematosus patients is a severe disease manifestation characterized by various clinical and histopathological alterations. The revised International Society of Nephrology/Renal Pathology Society 2003 classification defines the subclasses of lupus nephritis (LN) according to their pathological glomerular patterns, which has a crucial impact on the prognosis...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2017
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2017030263